Status epilepticus triggers long-lasting activation of complement C1q-C3 signaling in the hippocampus that correlates with seizure frequency in experimental epilepsy
Schartz ND, Wyatt-Johnson SK, Price LR, Colin SA, Brewster AL.
Neurobiology of Disease. 2018; 109:163-173.
Status epilepticus triggers time-dependent alterations in microglia abundance and morphological phenotypes in the hippocampus
Wyatt-Johnson SK, Herr SA, Brewster AL.
Frontiers in Neurology. 2017; 8:700.
Enhanced classical complement pathway activation and altered phagocytosis signaling molecules in human epilepsy
Wyatt SK, Witt T, Barbaro NM, Cohen-Gadol AA, Brewster AL.
Experimental Neurology. 2017; 295:184-193.
Early cardiac electrographic and molecular remodeling in a model of status epilepticus and acquired epilepsy.
Brewster AL, Marzec K, Hairston A, Ho M, Anderson AE, Lai YC.
Epilepsia. 2016; 57(11):1907-1915.
Spatiotemporal profile of Map2 and microglial changes in the hippocampal CA1 region following pilocarpine-induced status epilepticus.
Schartz ND, Herr SA, Madsen L, Butts SJ, Torres C, Mendez LB, Brewster AL.
Scientific Reports. 2016; 6:24988.
Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling.
Abiega O, Beccari S, Diaz-Aparicio I, Nadjar A, Layé S, Leyrolle Q, Gómez-Nicola D, Domercq M, Pérez-Samartín A, Sánchez-Zafra V, Paris I, Valero J, Savage JC, Hui CW, Tremblay MÈ, Deudero JJ, Brewster AL, Anderson AE, Zaldumbide L, Galbarriatu L, Marinas A, Vivanco Md, Matute C, Maletic-Savatic M, Encinas JM, Sierra A.
PLoS Biology. 2016; 14(5):e1002466.
Longitudinal variations of brain functional connectivity: A case report study based on a mouse model of epilepsy.
Erramuzpe A, Encinas JM, Sierra A, Maletic-Savatic M, Brewster AL, Anderson AE, Stramaglia S, Cortes JM.
F1000Research. 2015; 4:144.
Neuronal hyperactivity accelerates depletion of neural stem cells and impairs hippocampal neurogenesis.
Sierra A, Martín-Suárez S, Valcárcel-Martín R, Pascual-Brazo J, Aelvoet SA, Abiega O, Deudero JJ, Brewster AL, Bernales I, Anderson AE, Baekelandt V, Maletić-Savatić M, Encinas JM.
Cell Stem Cell. 2015; 16(5):488-503.
mTOR inhibition suppresses established epilepsy in a mouse model of cortical dysplasia.
Nguyen LH, Brewster AL, Clark ME, Regnier-Golanov A, Sunnen CN, Patil VV, D'Arcangelo G, Anderson AE.
Epilepsia. 2015; 56(4):636-46.
Rapamycin reverses status epilepticus-induced memory deficits and dendritic damage.
Brewster AL, Lugo JN, Patil VV, Lee WL, Qian Y, Vanegas F, Anderson AE.
PloS One. 2013; 8(3):e57808.
Differential dorso-ventral distributions of Kv4.2 and HCN proteins confer distinct integrative properties to hippocampal CA1 pyramidal cell distal dendrites.
Marcelin B, Lugo JN, Brewster AL, Liu Z, Lewis AS, McClelland S, Chetkovich DM, Baram TZ, Anderson AE, Becker A, Esclapez M, Bernard C.
Journal of Biological Chemistry. 2012; 287(21):17656-61.
Kv4.2 knockout mice have hippocampal-dependent learning and memory deficits.
Lugo JN, Brewster AL, Spencer CM, Anderson AE.
Learning & Memory. 2012; 19(5):182-9.
Hyperpolarization-activated cation current Ih of dentate gyrus granule cells is upregulated in human and rat temporal lobe epilepsy.
Surges R, Kukley M, Brewster A, Rüschenschmidt C, Schramm J, Baram TZ, Beck H, Dietrich D.
Biochemical and Biophysical Research Communications. 2012; 420(1):156-60.
Fever, febrile seizures and epileptogenesis
Dubé CM, McClelland S, Choy MK, Brewster AL, Noam Y, Baram TZ.
4th ed. Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, editors. Bethesda (MD): National Center for Biotechnology Information (US); 2012. Chapter
Inhibition of the mammalian target of rapamycin blocks epilepsy progression in NS-Pten conditional knockout mice.
Sunnen CN, Brewster AL, Lugo JN, Vanegas F, Turcios E, Mukhi S, Parghi D, D'Arcangelo G, Anderson AE.
Epilepsia. 2011; 52(11):2065-75.
Autonomic and cellular mechanisms mediating detrimental cardiac effects of status epilepticus.
Bealer SL, Little JG, Metcalf CS, Brewster AL, Anderson AE.
Epilepsy Research. 2010; 91(1):66-73.
Postnatal expression pattern of HCN channel isoforms in thalamic neurons: relationship to maturation of thalamocortical oscillations.
Kanyshkova T, Pawlowski M, Meuth P, Dubé C, Bender RA, Brewster AL, Baumann A, Baram TZ, Pape HC, Budde T.
Journal of Neuroscience. 2009; 29(27):8847-57.
Febrile seizures: mechanisms and relationship to epilepsy.
Dubé CM, Brewster AL, Baram TZ.
Brain & Development. 2009; 31(5):366-71.
Mechanisms of seizure-induced 'transcriptional channelopathy' of hyperpolarization-activated cyclic nucleotide gated (HCN) channels.
Richichi C, Brewster AL, Bender RA, Simeone TA, Zha Q, Yin HZ, Weiss JH, Baram TZ.
Neurobiology of Disease. 2008; 29(2):297-305.
Activity-dependent heteromerization of the hyperpolarization-activated, cyclic-nucleotide gated (HCN) channels: role of N-linked glycosylation.
Zha Q, Brewster AL, Richichi C, Bender RA, Baram TZ.
Journal of Neurochemistry. 2008; 105(1):68-77.
Quantitative analysis and subcellular distribution of mRNA and protein expression of the hyperpolarization-activated cyclic nucleotide-gated channels throughout development in rat hippocampus.
Brewster AL, Chen Y, Bender RA, Yeh A, Shigemoto R, Baram TZ.
Cerebral Cortex. 2007; 17(3):702-12.
Localization of HCN1 channels to presynaptic compartments: novel plasticity that may contribute to hippocampal maturation.
Bender RA, Kirschstein T, Kretz O, Brewster AL, Richichi C, Rüschenschmidt C, Shigemoto R, Beck H, Frotscher M, Baram TZ.
Journal of Neuroscience. 2007; 27(17):4697-706.
Fever, febrile seizures and epilepsy.
Dubé CM, Brewster AL, Richichi C, Zha Q, Baram TZ.
Trends in Neurosciences. 2007; 30(10):490-6.
Functional stabilization of weakened thalamic pacemaker channel regulation in rat absence epilepsy.
Kuisle M, Wanaverbecq N, Brewster AL, Frère SG, Pinault D, Baram TZ, Lüthi A.
Journal of Physiology. 2006; 575(Pt 1):83-100.
Regulated expression of HCN channels and cAMP levels shape the properties of the h current in developing rat hippocampus.
Surges R, Brewster AL, Bender RA, Beck H, Feuerstein TJ, Baram TZ.
European Journal of Neuroscience. 2006; 24(1):94-104.
Formation of heteromeric hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the hippocampus is regulated by developmental seizures.
Brewster AL, Bernard JA, Gall CM, Baram TZ.
Neurobiology of Disease. 2005; 19(1-2):200-7.
Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus.
Bender RA, Soleymani SV, Brewster AL, Nguyen ST, Beck H, Mathern GW, Baram TZ.
The Journal of Neuroscience. 2003; 23(17)826-36.
Developmental febrile seizures modulate hippocampal gene expression of hyperpolarization-activated channels in an isoform- and cell-specific manner.
Brewster A, Bender RA, Chen Y, Dube C, Eghbal-Ahmadi M, Baram TZ.
The Journal of neuroscience. 2002; 22(11):4591-9.
Differential and age-dependent expression of hyperpolarization-activated, cyclic nucleotide-gated cation channel isoforms 1-4 suggests evolving roles in the developing rat hippocampus.
Bender RA, Brewster A, Santoro B, Ludwig A, Hofmann F, Biel M, Baram TZ
Neuroscience. 2001; 106(4):689-98.